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Approved Drugs
Name: Dacomitinib
Formula: C24H25ClFN5O2
Similarity: 0.6134453781512605
Inhibitors
Name: Afatinib
Formula: C24H25ClFN5O3
Similarity: 1.0
Relative Targets: Epidermal growth factor receptor | Receptor tyrosine-protein kinase erbB-2 | Dipeptidyl peptidase 1 |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-6-[(3R)-tetrahydrofuran-3-yl]oxy-quinazolin-7-yl]-4-(dimethylamino)but-2-enamide
Formula: C24H25ClFN5O3
Similarity: 0.9595959595959596
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-cyano-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Formula: C25H25FN6O3
Similarity: 0.8584905660377359
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-[4-chloro-3-(trifluoromethyl)anilino]-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Formula: C25H25ClF3N5O3
Similarity: 0.8272727272727273
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(isopropylamino)but-2-enamide
Formula: C25H27ClFN5O3
Similarity: 0.8240740740740741
Relative Targets: Epidermal growth factor receptor |
Name: (Z)-N-[4-(3-Chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)-2-fluorobut-2-enamide
Formula: C24H24ClF2N5O3
Similarity: 0.8148148148148148
Relative Targets: Epidermal growth factor receptor | Potassium voltage-gated channel subfamily H member 2 |
Name: (E)-N-[4-(3-Chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)-2-fluorobut-2-enamide
Formula: C24H24ClF2N5O3
Similarity: 0.8148148148148148
Relative Targets: Epidermal growth factor receptor | Potassium voltage-gated channel subfamily H member 2 |
Name: N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]prop-2-enamide
Formula: C21H18ClFN4O3
Similarity: 0.7941176470588235
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(cyclopropylamino)but-2-enamide
Formula: C25H25ClFN5O3
Similarity: 0.7837837837837838
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dicyclopropylamino)but-2-enamide
Formula: C28H29ClFN5O3
Similarity: 0.7758620689655172
Relative Targets: Epidermal growth factor receptor |
Name: (E)-4-(dimethylamino)-N-[4-(3-ethynylanilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]but-2-enamide
Formula: C26H27N5O3
Similarity: 0.7727272727272727
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(3,3-difluoroazetidin-1-yl)but-2-enamide
Formula: C25H23ClF3N5O3
Similarity: 0.7565217391304347
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-[3-chloro-4-[(3-fluorophenyl)methoxy]anilino]-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Formula: C31H31ClFN5O4
Similarity: 0.744
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(1-piperidyl)but-2-enamide
Formula: C27H29ClFN5O3
Similarity: 0.7372881355932204
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-methoxy-quinazolin-6-yl]-4-[cyclopropyl(methyl)amino]but-2-enamide
Formula: C23H23ClFN5O2
Similarity: 0.7314814814814815
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-[3-chloro-4-(2-pyridylmethoxy)anilino]-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Formula: C30H31ClN6O4
Similarity: 0.728
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(4-oxo-1-piperidyl)but-2-enamide
Formula: C27H27ClFN5O4
Similarity: 0.725
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-[(3S)-tetrahydrofuran-3-yl]oxy-quinazolin-6-yl]-4-(1-oxidothiomorpholin-1-ium-4-yl)but-2-enamide
Formula: C26H27ClFN5O4S
Similarity: 0.725
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-(2-methoxyethoxy)quinazolin-6-yl]-4-(dimethylamino)but-2-enamide
Formula: C23H25ClFN5O3
Similarity: 0.7117117117117117
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[4-(3-chloro-4-fluoro-anilino)-7-ethoxy-quinazolin-6-yl]-4-[cyclopropyl(methyl)amino]but-2-enamide
Formula: C24H25ClFN5O2
Similarity: 0.7117117117117117
Relative Targets: Epidermal growth factor receptor |