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Approved Drugs

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Inhibitors

Name:  1-[4-[5-chloro-2-[4-[4-(2-hydroxyethyl)piperazin-1-yl]anilino]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C24H31ClN6O3

Similarity:  0.8269230769230769

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[5-chloro-2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C23H28ClFN6O2

Similarity:  0.7884615384615384

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[[2-[4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-1-piperidyl]prop-2-en-1-one

Formula:  C25H31N7O2

Similarity:  0.7522935779816514

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[2-[4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C25H30N6O2S

Similarity:  0.7522935779816514

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[5-chloro-2-[4-[[4-(hydroxymethyl)-1-piperidyl]methyl]anilino]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C25H32ClN5O3

Similarity:  0.6521739130434783

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[2-[4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxy-1-piperidyl]propan-1-one

Formula:  C25H32N6O2S

Similarity:  0.6324786324786325

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-1-piperidyl]prop-2-en-1-one

Formula:  C25H30FN7O2

Similarity:  0.6218487394957983

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[2-[3-fluoro-4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C25H29FN6O2S

Similarity:  0.6218487394957983

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-1-piperidyl]prop-2-en-1-one

Formula:  C26H33N7O3

Similarity:  0.6065573770491803

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]thieno[3,2-d]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C26H32N6O3S

Similarity:  0.6065573770491803

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[2-(4-morpholinoanilino)thieno[3,2-d]pyrimidin-4-yl]oxy-1-piperidyl]prop-2-en-1-one

Formula:  C24H27N5O3S

Similarity:  0.6016949152542372

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[2-[5-Chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

Formula:  C24H25ClN6O2

Similarity:  0.5714285714285714

Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  | Dual specificity mitogen-activated protein kinase kinase 1  |

Name:  N-[3-[5-chloro-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

Formula:  C24H25ClN6O2

Similarity:  0.5714285714285714

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[3-[[2-[4-(4-methylpiperazin-1-yl)anilino]-9H-purin-6-yl]amino]-1-piperidyl]prop-2-en-1-one

Formula:  C24H31N9O

Similarity:  0.5655737704918032

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[[2-[4-(4-acetylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-1-piperidyl]prop-2-en-1-one

Formula:  C31H36N10O3

Similarity:  0.5531914893617021

Relative Targets:   Tyrosine-protein kinase ITK/TSK  |

Name:  N-[2-[5-Cyclopropyl-2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

Formula:  C27H30N6O2

Similarity:  0.544

Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  | Dual specificity mitogen-activated protein kinase kinase 1  |

Name:  7-[4-(4-methylpiperazin-1-yl)anilino]-3-phenyl-1-[(3S)-1-prop-2-enoylpyrrolidin-3-yl]-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C30H34N8O2

Similarity:  0.5407407407407407

Relative Targets:   Epidermal growth factor receptor  |

Name:  1-[4-[[2-[4-(4-but-3-ynylpiperazin-1-yl)anilino]-5-[6-(methylamino)pyrazin-2-yl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]-1-piperidyl]prop-2-en-1-one

Formula:  C33H38N10O2

Similarity:  0.5379310344827586

Relative Targets:   Tyrosine-protein kinase ITK/TSK  |

Name:  1-[(3R)-3-[[9-isopropyl-6-[4-(4-methylpiperazin-1-yl)anilino]purin-2-yl]amino]pyrrolidin-1-yl]prop-2-en-1-one

Formula:  C26H35N9O

Similarity:  0.5354330708661418

Relative Targets:   Epidermal growth factor receptor  |