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Approved Drugs

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Inhibitors

Name:  N-[3-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide

Formula:  C25H28ClN7O2

Similarity:  0.68

Relative Targets:   Epidermal growth factor receptor  |

Name:  4-[[4-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-chloro-pyrimidin-4-yl]amino]anilino]methyl]benzenesulfonyl fluoride

Formula:  C30H31ClFN7O4S

Similarity:  0.6666666666666666

Relative Targets:   Epidermal growth factor receptor  |

Name:  Rociletinib

Formula:  C27H28F3N7O3

Similarity:  0.6567164179104478

Relative Targets:   Epidermal growth factor receptor  |

Name:  (4-fluorophenyl) 3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-chloro-pyrimidin-4-yl]amino]benzoate

Formula:  C30H28ClFN6O4

Similarity:  0.6428571428571429

Relative Targets:   Epidermal growth factor receptor  |

Name:  [2-[[2-[3-(4-Acetylpiperazin-1-yl)anilino]-5-chloropyrimidin-4-yl]amino]phenyl] prop-2-enoate

Formula:  C25H25ClN6O3

Similarity:  0.5789473684210527

Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  | Dual specificity mitogen-activated protein kinase kinase 1  |

Name:  [2-[[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl] prop-2-enoate

Formula:  C25H27ClN6O3

Similarity:  0.5555555555555556

Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  |

Name:  N-[3-[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]oxyphenyl]prop-2-enamide

Formula:  C27H27F3N6O4

Similarity:  0.5524475524475524

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C30H31N7O4

Similarity:  0.54421768707483

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  WZ4002

Formula:  C25H27ClN6O3

Similarity:  0.5441176470588235

Relative Targets:   Epidermal growth factor receptor  | Dipeptidyl peptidase 1  |

Name:  N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide

Formula:  C25H27ClN6O2S

Similarity:  0.5441176470588235

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-3-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide

Formula:  C27H28F3N7O3

Similarity:  0.5416666666666666

Relative Targets:   Epidermal growth factor receptor  |

Name:  2-[[5-chloro-2-(2-methoxy-4-morpholino-anilino)pyrimidin-4-yl]amino]-N-methyl-benzamide

Formula:  C23H25ClN6O3

Similarity:  0.5298507462686567

Relative Targets:   Focal adhesion kinase 1  |

Name:  (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-cyclopropylprop-2-enamide

Formula:  C28H31ClN6O3

Similarity:  0.5103448275862069

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[5-chloro-2-[2-methoxy-4-(4-morpholino-1-piperidyl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide

Formula:  C30H35ClN8O4

Similarity:  0.5096774193548387

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxy-2-fluoro-phenyl]prop-2-enamide

Formula:  C25H26ClFN6O3

Similarity:  0.5035460992907801

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[2-[4-[4-(2-fluoroethyl)piperazin-1-yl]-2-methoxy-anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide

Formula:  C27H31FN8O3

Similarity:  0.5

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide

Formula:  C26H30N8O3

Similarity:  0.5

Relative Targets:   Epidermal growth factor receptor  |