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Approved Drugs
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Inhibitors
Name:  N-[3-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Formula:  C25H28ClN7O2
Similarity:  0.68
Relative Targets:   Epidermal growth factor receptor  |
Name:  4-[[4-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-chloro-pyrimidin-4-yl]amino]anilino]methyl]benzenesulfonyl fluoride
Formula:  C30H31ClFN7O4S
Similarity:  0.6666666666666666
Relative Targets:   Epidermal growth factor receptor  |
Name:  Rociletinib
Formula:  C27H28F3N7O3
Similarity:  0.6567164179104478
Relative Targets:   Epidermal growth factor receptor  |
Name:  (4-fluorophenyl) 3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-chloro-pyrimidin-4-yl]amino]benzoate
Formula:  C30H28ClFN6O4
Similarity:  0.6428571428571429
Relative Targets:   Epidermal growth factor receptor  |
Name:  Jak3-IN-1
Formula:  C26H30ClN7O2
Similarity:  0.6015037593984962
Relative Targets:   Serine/threonine-protein kinase Sgk1  | Epidermal growth factor receptor  | Platelet-derived growth factor receptor beta  | Tyrosine-protein kinase JAK1  | Non-receptor tyrosine-protein kinase TYK2  | Dual specificity protein kinase TTK  | Receptor-type tyrosine-protein kinase FLT3  | Tyrosine-protein kinase Blk  | Tyrosine-protein kinase JAK3  | Focal adhesion kinase 1  | Tyrosine-protein kinase BTK  | Tyrosine-protein kinase ITK/TSK  | Receptor tyrosine-protein kinase erbB-4  |
Name:  [2-[[2-[3-(4-Acetylpiperazin-1-yl)anilino]-5-chloropyrimidin-4-yl]amino]phenyl] prop-2-enoate
Formula:  C25H25ClN6O3
Similarity:  0.5789473684210527
Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  | Dual specificity mitogen-activated protein kinase kinase 1  |
Name:  [2-[[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl] prop-2-enoate
Formula:  C25H27ClN6O3
Similarity:  0.5555555555555556
Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  |
Name:  N-[3-[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Formula:  C27H27F3N6O4
Similarity:  0.5524475524475524
Relative Targets:   Epidermal growth factor receptor  |
Name:  N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide
Formula:  C30H31N7O4
Similarity:  0.54421768707483
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  WZ4002
Formula:  C25H27ClN6O3
Similarity:  0.5441176470588235
Relative Targets:   Epidermal growth factor receptor  | Dipeptidyl peptidase 1  |
Name:  N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]sulfanylphenyl]prop-2-enamide
Formula:  C25H27ClN6O2S
Similarity:  0.5441176470588235
Relative Targets:   Epidermal growth factor receptor  |
Name:  N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-3-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Formula:  C27H28F3N7O3
Similarity:  0.5416666666666666
Relative Targets:   Epidermal growth factor receptor  |
Name:  2-[[5-chloro-2-(2-methoxy-4-morpholino-anilino)pyrimidin-4-yl]amino]-N-methyl-benzamide
Formula:  C23H25ClN6O3
Similarity:  0.5298507462686567
Relative Targets:   Focal adhesion kinase 1  |
Name:  (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-cyclopropylprop-2-enamide
Formula:  C28H31ClN6O3
Similarity:  0.5103448275862069
Relative Targets:   Epidermal growth factor receptor  |
Name:  N-[3-[[5-chloro-2-[2-methoxy-4-(4-morpholino-1-piperidyl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Formula:  C30H35ClN8O4
Similarity:  0.5096774193548387
Relative Targets:   Epidermal growth factor receptor  |
Name:  N-[3-[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxy-2-fluoro-phenyl]prop-2-enamide
Formula:  C25H26ClFN6O3
Similarity:  0.5035460992907801
Relative Targets:   Epidermal growth factor receptor  |
Name:  N-[3-[[2-[4-[4-(2-fluoroethyl)piperazin-1-yl]-2-methoxy-anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Formula:  C27H31FN8O3
Similarity:  0.5
Relative Targets:   Epidermal growth factor receptor  |
Name:  N-[3-[[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamoylamino]phenyl]prop-2-enamide
Formula:  C26H30N8O3
Similarity:  0.5
Relative Targets:   Epidermal growth factor receptor  |