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Approved Drugs
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Inhibitors
Name: 2-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-chloro-pyrimidin-4-yl]amino]anilino]ethanesulfonyl fluoride
Formula: C25H29ClFN7O4S
Similarity: 0.6428571428571429
Relative Targets: Epidermal growth factor receptor |
Name: 4-[[4-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-chloro-pyrimidin-4-yl]amino]anilino]methyl]benzenesulfonyl fluoride
Formula: C30H31ClFN7O4S
Similarity: 0.6333333333333333
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-cyano-3-(4-fluorophenyl)prop-2-enamide
Formula: C32H29ClFN7O3
Similarity: 0.6078431372549019
Relative Targets: Epidermal growth factor receptor |
Name: (Z)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-(4-fluorophenyl)-2-(trifluoromethyl)prop-2-enamide
Formula: C32H29ClF4N6O3
Similarity: 0.5923566878980892
Relative Targets: Epidermal growth factor receptor |
Name: Rociletinib
Formula: C27H28F3N7O3
Similarity: 0.589041095890411
Relative Targets: Epidermal growth factor receptor |
Name: [2-[[2-[3-(4-Acetylpiperazin-1-yl)anilino]-5-chloropyrimidin-4-yl]amino]phenyl] prop-2-enoate
Formula: C25H25ClN6O3
Similarity: 0.5827338129496403
Relative Targets: Mitogen-activated protein kinase kinase kinase 7 | Dual specificity mitogen-activated protein kinase kinase 1 |
Name: N-[3-[[5-chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
Formula: C25H28ClN7O2
Similarity: 0.5827338129496403
Relative Targets: Epidermal growth factor receptor |
Name: N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide
Formula: C30H31N7O4
Similarity: 0.5592105263157895
Relative Targets: Tyrosine-protein kinase JAK3 |
Name: N-[3-[2-[4-(4-acetylpiperazin-1-yl)-2-methoxy-anilino]-5-(trifluoromethyl)pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Formula: C27H27F3N6O4
Similarity: 0.5570469798657718
Relative Targets: Epidermal growth factor receptor |
Name: (Z)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-(4-methoxyphenyl)-2-(trifluoromethyl)prop-2-enamide
Formula: C33H32ClF3N6O4
Similarity: 0.5521472392638037
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-cyano-3-(4-nitrophenyl)prop-2-enamide
Formula: C32H29ClN8O5
Similarity: 0.5398773006134969
Relative Targets: Epidermal growth factor receptor |
Name: [2-[[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]amino]phenyl] prop-2-enoate
Formula: C25H27ClN6O3
Similarity: 0.5384615384615384
Relative Targets: Mitogen-activated protein kinase kinase kinase 7 |
Name: (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-cyano-3-(4-methylsulfanylphenyl)prop-2-enamide
Formula: C33H32ClN7O3S
Similarity: 0.5370370370370371
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-cyano-3-(4-cyanophenyl)prop-2-enamide
Formula: C33H29ClN8O3
Similarity: 0.5370370370370371
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-cyano-3-[4-(dimethylamino)phenyl]prop-2-enamide
Formula: C34H35ClN8O3
Similarity: 0.5304878048780488
Relative Targets: Epidermal growth factor receptor |
Name: WZ4002
Formula: C25H27ClN6O3
Similarity: 0.5277777777777778
Relative Targets: Epidermal growth factor receptor | Dipeptidyl peptidase 1 |
Name: Jak3-IN-1
Formula: C26H30ClN7O2
Similarity: 0.5273972602739726
Relative Targets: Serine/threonine-protein kinase Sgk1 | Epidermal growth factor receptor | Platelet-derived growth factor receptor beta | Tyrosine-protein kinase JAK1 | Non-receptor tyrosine-protein kinase TYK2 | Dual specificity protein kinase TTK | Receptor-type tyrosine-protein kinase FLT3 | Tyrosine-protein kinase Blk | Tyrosine-protein kinase JAK3 | Focal adhesion kinase 1 | Tyrosine-protein kinase BTK | Tyrosine-protein kinase ITK/TSK | Receptor tyrosine-protein kinase erbB-4 |
Name: (Z)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-3-[4-(dimethylamino)phenyl]-2-(trifluoromethyl)prop-2-enamide
Formula: C34H35ClF3N7O3
Similarity: 0.5269461077844312
Relative Targets: Epidermal growth factor receptor |
Name: (E)-N-[3-[5-Chloro-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]oxyphenyl]-2-cyano-3-pyridin-4-ylprop-2-enamide
Formula: C31H29ClN8O3
Similarity: 0.525
Relative Targets: Epidermal growth factor receptor |