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Approved Drugs

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Inhibitors

Name:  N-[3-[3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C34H36N8O3

Similarity:  0.7342657342657343

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[4-[3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]cyclohexyl]prop-2-enamide

Formula:  C34H42N8O3

Similarity:  0.7342657342657343

Relative Targets:   Epidermal growth factor receptor  |

Name:  3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1-[(3R)-1-prop-2-enoylpyrrolidin-3-yl]-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C32H38N8O3

Similarity:  0.7285714285714285

Relative Targets:   Epidermal growth factor receptor  |

Name:  3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1-[(3S)-1-prop-2-enoylpyrrolidin-3-yl]-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C32H38N8O3

Similarity:  0.7285714285714285

Relative Targets:   Epidermal growth factor receptor  |

Name:  3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1-[(3R)-1-prop-2-enoyl-3-piperidyl]-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C33H40N8O3

Similarity:  0.7132867132867133

Relative Targets:   Epidermal growth factor receptor  |

Name:  3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1-[(3S)-1-prop-2-enoyl-3-piperidyl]-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C33H40N8O3

Similarity:  0.7132867132867133

Relative Targets:   Epidermal growth factor receptor  |

Name:  3-benzyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-1-(1-prop-2-enoyl-4-piperidyl)-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C33H40N8O3

Similarity:  0.7132867132867133

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C28H32N8O3

Similarity:  0.6357142857142857

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-3-phenyl-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C33H34N8O3

Similarity:  0.6333333333333333

Relative Targets:   Epidermal growth factor receptor  |

Name:  7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-phenyl-1-[(3S)-1-prop-2-enoylpyrrolidin-3-yl]-4H-pyrimido[4,5-d]pyrimidin-2-one

Formula:  C31H36N8O3

Similarity:  0.6258503401360545

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[3-isopropyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C30H36N8O3

Similarity:  0.6137931034482759

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[3-cyclopropyl-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C30H34N8O3

Similarity:  0.6095890410958904

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[7-[2-methoxy-4-(4-methyl-1,4-diazepan-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C29H34N8O3

Similarity:  0.6

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[7-[2-ethoxy-4-(4-methylpiperazin-1-yl)anilino]-3-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C29H34N8O3

Similarity:  0.589041095890411

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C29H31N7O3

Similarity:  0.5862068965517241

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[3-(4-benzyloxyphenyl)-7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C40H40N8O4

Similarity:  0.5823529411764706

Relative Targets:   Epidermal growth factor receptor  |

Name:  N-[3-[[2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-5-methyl-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C30H33N7O3

Similarity:  0.5782312925170068

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[5-ethyl-2-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C31H35N7O3

Similarity:  0.5771812080536913

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[7-[2-methoxy-4-(4-methylpiperazin-1-yl)anilino]-3-(2-naphthyl)-2-oxo-4H-pyrimido[4,5-d]pyrimidin-1-yl]phenyl]prop-2-enamide

Formula:  C37H36N8O3

Similarity:  0.5766871165644172

Relative Targets:   Epidermal growth factor receptor  |