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Inhibitors

Name:  N-[3-[[[5-Chloro-2-[[1-(2-hydroxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide

Formula:  C19H20ClN7O2

Similarity:  0.8571428571428571

Relative Targets:   Tyrosine-protein kinase JAK1  | Non-receptor tyrosine-protein kinase TYK2  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide

Formula:  C18H18ClN7O

Similarity:  0.7912087912087912

Relative Targets:   Tyrosine-protein kinase JAK1  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C23H23N7O3

Similarity:  0.6605504587155964

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide

Formula:  C19H20N6O2

Similarity:  0.6565656565656566

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[2-[5-Chloro-2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

Formula:  C19H19ClN6O3

Similarity:  0.6407766990291263

Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  | Dual specificity mitogen-activated protein kinase kinase 1  |

Name:  N-[2-[5-chloro-2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide

Formula:  C19H19ClN6O3

Similarity:  0.6407766990291263

Relative Targets:   Nuclear receptor subfamily 2 group C member 2  |

Name:  N-[3-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide

Formula:  C19H20N6O2

Similarity:  0.5922330097087378

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[4-[2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide

Formula:  C19H20N6O2

Similarity:  0.5769230769230769

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[2-[[1-(2-hydroxyethyl)pyrazol-4-yl]amino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C22H21N7O3

Similarity:  0.5614035087719298

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[[5-Chloro-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide

Formula:  C24H25ClN6O2

Similarity:  0.5555555555555556

Relative Targets:   Tyrosine-protein kinase JAK1  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[[5-Chloro-2-(3,5-difluoro-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide

Formula:  C24H23ClF2N6O2

Similarity:  0.5371900826446281

Relative Targets:   Tyrosine-protein kinase JAK1  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |

Name:  N-[2-[3-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]anilino]-2-oxo-ethyl]prop-2-enamide

Formula:  C21H23N7O3

Similarity:  0.5350877192982456

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[4-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide

Formula:  C19H20N6O2

Similarity:  0.5327102803738317

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[4-[[5-chloro-4-[[3-(prop-2-enoylamino)phenyl]methylamino]pyrimidin-2-yl]amino]pyrazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]pentanamide

Formula:  C35H47ClN10O6S

Similarity:  0.5094339622641509

Relative Targets:   Tyrosine-protein kinase JAK1  | Non-receptor tyrosine-protein kinase TYK2  | Tyrosine-protein kinase JAK3  |

Name:  N-[3-[[2-[(1-methylpyrazol-4-yl)amino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide

Formula:  C21H19N7O2

Similarity:  0.5087719298245614

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  (E)-N-[3-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]but-2-enamide

Formula:  C20H22N6O2

Similarity:  0.5045045045045045

Relative Targets:   Tyrosine-protein kinase JAK3  |

Name:  N-[3-[2-[[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]amino]-5-methyl-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide

Formula:  C24H26N8O2

Similarity:  0.5041322314049587

Relative Targets:   Epidermal growth factor receptor  |