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Approved Drugs
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Inhibitors
Name:  N-[3-[[[5-Chloro-2-[[1-(2-hydroxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide
Formula:  C19H20ClN7O2
Similarity:  0.8571428571428571
Relative Targets:   Tyrosine-protein kinase JAK1  | Non-receptor tyrosine-protein kinase TYK2  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |
Name:  N-[3-[[[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide
Formula:  C18H18ClN7O
Similarity:  0.7912087912087912
Relative Targets:   Tyrosine-protein kinase JAK1  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |
Name:  N-[3-[[2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide
Formula:  C23H23N7O3
Similarity:  0.6605504587155964
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[3-[2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide
Formula:  C19H20N6O2
Similarity:  0.6565656565656566
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[2-[5-Chloro-2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Formula:  C19H19ClN6O3
Similarity:  0.6407766990291263
Relative Targets:   Mitogen-activated protein kinase kinase kinase 7  | Dual specificity mitogen-activated protein kinase kinase 1  |
Name:  N-[2-[5-chloro-2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]oxyphenyl]prop-2-enamide
Formula:  C19H19ClN6O3
Similarity:  0.6407766990291263
Relative Targets:   Nuclear receptor subfamily 2 group C member 2  |
Name:  N-[3-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide
Formula:  C19H20N6O2
Similarity:  0.5922330097087378
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[4-[2-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide
Formula:  C19H20N6O2
Similarity:  0.5769230769230769
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[3-[[2-[[1-(2-hydroxyethyl)pyrazol-4-yl]amino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide
Formula:  C22H21N7O3
Similarity:  0.5614035087719298
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[3-[[[5-Chloro-2-(4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide
Formula:  C24H25ClN6O2
Similarity:  0.5555555555555556
Relative Targets:   Tyrosine-protein kinase JAK1  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |
Name:  N-[3-[[[5-Chloro-2-(3,5-difluoro-4-morpholin-4-ylanilino)pyrimidin-4-yl]amino]methyl]phenyl]prop-2-enamide
Formula:  C24H23ClF2N6O2
Similarity:  0.5371900826446281
Relative Targets:   Tyrosine-protein kinase JAK1  | Dual specificity protein kinase TTK  | Tyrosine-protein kinase JAK3  |
Name:  Jak3-IN-1
Formula:  C26H30ClN7O2
Similarity:  0.5365853658536586
Relative Targets:   Serine/threonine-protein kinase Sgk1  | Epidermal growth factor receptor  | Platelet-derived growth factor receptor beta  | Tyrosine-protein kinase JAK1  | Non-receptor tyrosine-protein kinase TYK2  | Dual specificity protein kinase TTK  | Receptor-type tyrosine-protein kinase FLT3  | Tyrosine-protein kinase Blk  | Tyrosine-protein kinase JAK3  | Focal adhesion kinase 1  | Tyrosine-protein kinase BTK  | Tyrosine-protein kinase ITK/TSK  | Receptor tyrosine-protein kinase erbB-4  |
Name:  N-[2-[3-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]anilino]-2-oxo-ethyl]prop-2-enamide
Formula:  C21H23N7O3
Similarity:  0.5350877192982456
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[4-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]prop-2-enamide
Formula:  C19H20N6O2
Similarity:  0.5327102803738317
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  5-[(3As,4S,6aR)-2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl]-N-[2-[2-[2-[2-[4-[[5-chloro-4-[[3-(prop-2-enoylamino)phenyl]methylamino]pyrimidin-2-yl]amino]pyrazol-1-yl]ethoxy]ethoxy]ethoxy]ethyl]pentanamide
Formula:  C35H47ClN10O6S
Similarity:  0.5094339622641509
Relative Targets:   Tyrosine-protein kinase JAK1  | Non-receptor tyrosine-protein kinase TYK2  | Tyrosine-protein kinase JAK3  |
Name:  N-[3-[[2-[(1-methylpyrazol-4-yl)amino]-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]methyl]phenyl]prop-2-enamide
Formula:  C21H19N7O2
Similarity:  0.5087719298245614
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  (E)-N-[3-[6-[[1-(2-methoxyethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]phenyl]but-2-enamide
Formula:  C20H22N6O2
Similarity:  0.5045045045045045
Relative Targets:   Tyrosine-protein kinase JAK3  |
Name:  N-[3-[2-[[1-[2-(dimethylamino)ethyl]pyrazol-4-yl]amino]-5-methyl-7-oxo-pyrido[2,3-d]pyrimidin-8-yl]phenyl]prop-2-enamide
Formula:  C24H26N8O2
Similarity:  0.5041322314049587
Relative Targets:   Epidermal growth factor receptor  |