Protein-glutamine gamma-glutamyltransferase E
Target information
- CovInDB Protein
- Q08188
- Name
- Protein-glutamine gamma-glutamyltransferase E
- Encoding Gene
- TGM3
- Synonyms
-
- Transglutaminase E
- TG(E)
- TGE
- TGase E
- Transglutaminase-3
- TGase-3
- Taxonomy
- Homo sapiens (Human)
- Description
-
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.
- Sequence
-
MAALGVQSINWQTAFNRQAHHTDKFSSQELILRRGQNFQVLMIMNKGLGSNERLEFIVSTGPYPSESAMTKAVFPLSNGSSGGWSAVLQASNGNTLTISISSPASAPIGRYTMALQIFSQGGISSVKLGTFILLFNPWLNVDSVFMGNHAEREEYVQEDAGIIFVGSTNRIGMIGWNFGQFEEDILSICLSILDRSLNFRRDAATDVASRNDPKYVGRVLSAMINSNDDNGVLAGNWSGTYTGGRDPRSWNGSVEILKNWKKSGFSPVRYGQCWVFAGTLNTALRSLGIPSRVITNFNSAHDTDRNLSVDVYYDPMGNPLDKGSDSVWNFHVWNEGWFVRSDLGPSYGGWQVLDATPQERSQGVFQCGPASVIGVREGDVQLNFDMPFIFAEVNADRITWLYDNTTGKQWKNSVNSHTIGRYISTKAVGSNARMDVTDKYKYPEGSDQERQVFQKALGKLKPNTPFAATSSMGLETEEQEPSIIGKLKVAGMLAVGKEVNLVLLLKNLSRDTKTVTVNMTAWTIIYNGTLVHEVWKDSATMSLDPEEEAEHPIKISYAQYEKYLKSDNMIRITAVCKVPDESEVVVERDIILDNPTLTLEVLNEARVRKPVNVQMLFSNPLDEPVRDCVLMVEGSGLLLGNLKIDVPTLGPKEGSRVRFDILPSRSGTKQLLADFSCNKFPAIKAMLSIDVAE
- Active Site
-
Feature Key Position(s) Description Metal binding 222 Calcium 1; via carbonyl oxygen Metal binding 225 Calcium 1 Metal binding 227 Calcium 1; via carbonyl oxygen Metal binding 228 Calcium 1 Metal binding 230 Calcium 1; via carbonyl oxygen Active site 273 None Metal binding 302 Calcium 2 Metal binding 304 Calcium 2 Metal binding 306 Calcium 2 Metal binding 308 Calcium 2; via carbonyl oxygen Metal binding 325 Calcium 2 Active site 331 None Active site 354 None Metal binding 394 Calcium 3 Metal binding 416 Calcium 3; via carbonyl oxygen Metal binding 444 Calcium 3 Metal binding 449 Calcium 3 - Structure
-
PDB: 1NUF
Show Surface - Reference
- UniProt
Covalent Inhibitors
| Structure | Rank | ID | Warhead | Reaction Mechanism | Target Site | Activity Type | Relation | Value | Unit | Experiment Method | Assay | Reference |
|---|