Methionine aminopeptidase 1
Target information
- CovInDB Protein
- P53582
- Name
- Methionine aminopeptidase 1
- Encoding Gene
- METAP1
- Synonyms
-
- MAP 1
- MetAP 1
- Peptidase M 1
- Taxonomy
- Homo sapiens (Human)
- Description
-
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
- Sequence
-
MAAVETRVCETDGCSSEAKLQCPTCIKLGIQGSYFCSQECFKGSWATHKLLHKKAKDEKAKREVSSWTVEGDINTDPWAGYRYTGKLRPHYPLMPTRPVPSYIQRPDYADHPLGMSESEQALKGTSQIKLLSSEDIEGMRLVCRLAREVLDVAAGMIKPGVTTEEIDHAVHLACIARNCYPSPLNYYNFPKSCCTSVNEVICHGIPDRRPLQEGDIVNVDITLYRNGYHGDLNETFFVGEVDDGARKLVQTTYECLMQAIDAVKPGVRYRELGNIIQKHAQANGFSVVRSYCGHGIHKLFHTAPNVPHYAKNKAVGVMKSGHVFTIEPMICEGGWQDETWPDGWTAVTRDGKRSAQFEHTLLVTDTGCEILTRRLDSARPHFMSQF
- Active Site
-
Feature Key Position(s) Description Binding site 203 Substrate Metal binding 220 Divalent metal cation 1 Metal binding 231 Divalent metal cation 1 Metal binding 231 Divalent metal cation 2; catalytic Metal binding 294 Divalent metal cation 2; catalytic; via tele nitrogen Binding site 301 Substrate Metal binding 327 Divalent metal cation 2; catalytic Metal binding 358 Divalent metal cation 1 Metal binding 358 Divalent metal cation 2; catalytic - Structure
-
Check covalent ligand-protein complexes.
PDB: 2GZ5
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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