Protein-glutamine gamma-glutamyltransferase 2
Target information
- CovInDB Protein
- P21980
- Name
- Protein-glutamine gamma-glutamyltransferase 2
- Encoding Gene
- TGM2
- Synonyms
-
- Tissue transglutaminase
- Transglutaminase C
- TG(C)
- TGC
- TGase C
- Transglutaminase H
- TGase H
- Transglutaminase-2
- TGase-2
- Taxonomy
- Homo sapiens (Human)
- Description
-
Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.
- Sequence
-
MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA
- Active Site
-
Feature Key Position(s) Description Active site 277 None Active site 335 None Active site 358 None Metal binding 398 Calcium Metal binding 400 Calcium Metal binding 447 Calcium Metal binding 452 Calcium - Structure
-
Check covalent ligand-protein complexes.
PDB:  3S3P
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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