Protein-glutamine gamma-glutamyltransferase 2

Target information

CovInDB Protein
P21980
Name
Protein-glutamine gamma-glutamyltransferase 2
Encoding Gene
TGM2
Synonyms
  • Tissue transglutaminase
  • Transglutaminase C
  • TG(C)
  • TGC
  • TGase C
  • Transglutaminase H
  • TGase H
  • Transglutaminase-2
  • TGase-2
Taxonomy
Homo sapiens (Human)
Description

Catalyzes the cross-linking of proteins, such as WDR54, and the conjugation of polyamines to proteins.

Sequence

MAEELVLERCDLELETNGRDHHTADLCREKLVVRRGQPFWLTLHFEGRNYEASVDSLTFSVVTGPAPSQEAGTKARFPLRDAVEEGDWTATVVDQQDCTLSLQLTTPANAPIGLYRLSLEASTGYQGSSFVLGHFILLFNAWCPADAVYLDSEEERQEYVLTQQGFIYQGSAKFIKNIPWNFGQFEDGILDICLILLDVNPKFLKNAGRDCSRRSSPVYVGRVVSGMVNCNDDQGVLLGRWDNNYGDGVSPMSWIGSVDILRRWKNHGCQRVKYGQCWVFAAVACTVLRCLGIPTRVVTNYNSAHDQNSNLLIEYFRNEFGEIQGDKSEMIWNFHCWVESWMTRPDLQPGYEGWQALDPTPQEKSEGTYCCGPVPVRAIKEGDLSTKYDAPFVFAEVNADVVDWIQQDDGSVHKSINRSLIVGLKISTKSVGRDEREDITHTYKYPEGSSEEREAFTRANHLNKLAEKEETGMAMRIRVGQSMNMGSDFDVFAHITNNTAEEYVCRLLLCARTVSYNGILGPECGTKYLLNLNLEPFSEKSVPLCILYEKYRDCLTESNLIKVRALLVEPVINSYLLAERDLYLENPEIKIRILGEPKQKRKLVAEVSLQNPLPVALEGCTFTVEGAGLTEEQKTVEIPDPVEAGEEVKVRMDLLPLHMGLHKLVVNFESDKLKAVKGFRNVIIGPA

Active Site
Feature Key Position(s) Description
Active site 277 None
Active site 335 None
Active site 358 None
Metal binding 398 Calcium
Metal binding 400 Calcium
Metal binding 447 Calcium
Metal binding 452 Calcium
Structure

Check covalent ligand-protein complexes.

PDB:  3S3P

Show Surface
Site View
Reference
UniProt



Covalent Inhibitors

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Structure Rank ID Warhead Reaction Mechanism Target Site Activity Type Relation Value Unit Experiment Method Assay Reference