Tyrosine-protein phosphatase YopH
Target information
- CovInDB Protein
- P15273
- Name
- Tyrosine-protein phosphatase YopH
- Encoding Gene
- yopH
- Synonyms
-
- Virulence protein
- Taxonomy
- Yersinia enterocolitica
- Description
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Essential virulence determinant. This protein is a protein tyrosine phosphatase. The essential function of YopH in Yersinia pathogenesis is host-protein dephosphorylation. It contributes to the ability of the bacteria to resist phagocytosis by peritoneal macrophages.
- Sequence
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MNLSLSDLHRQVSRLVQQESGDCTGKLRGNVAANKETTFQGLTIASGARESEKVFAQTVLSHVANIVLTQEDTAKLLQSTVKHNLNNYELRSVGNGNSVLVSLRSDQMTLQDAKVLLEAALRQESGARGHVSSHSHSVLHAPGTPVREGLRSHLDPRTPPLPPRERPHTSGHHGAGEARATAPSTVSPYGPEARAELSSRLTTLRNTLAPATNDPRYLQACGGEKLNRFRDIQCCRQTAVRADLNANYIQVGNTRTIACQYPLQSQLESHFRMLAENRTPVLAVLASSSEIANQRFGMPDYFRQSGTYGSITVESKMTQQVGLGDGIMADMYTLTIREAGQKTISVPVVHVGNWPDQTAVSSEVTKALASLVDQTAETKRNMYESKGSSAVADDSKLRPVIHCRAGVGRTAQLIGAMCMNDSRNSQLSVEDMVSQMRVQRNGIMVQKDEQLDVLIKLAEGQGRPLLNS
- Active Site
-
Feature Key Position(s) Description Active site 403 Phosphocysteine intermediate - Structure
-
Check covalent ligand-protein complexes.
PDB: 3BLU
Show SurfaceSite View - Reference
- UniProt
Covalent Inhibitors
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