Thyroid hormone receptor beta

Target information

CovInDB Protein
P10828
Name
Thyroid hormone receptor beta
Encoding Gene
THRB
Synonyms
  • Thyroid hormone receptor beta
  • Nuclear receptor subfamily 1 group A member 2
  • c-erbA-2
  • c-erbA-beta
Taxonomy
Homo sapiens (Human)
Description

Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.

Sequence

MTPNSMTENGLTAWDKPKHCPDREHDWKLVGMSEACLHRKSHSERRSTLKNEQSSPHLIQTTWTSSIFHLDHDDVNDQSVSSAQTFQTEEKKCKGYIPSYLDKDELCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPSYSCKYEGKCVIDKVTRNQCQECRFKKCIYVGMATDLVLDDSKRLAKRKLIEENREKRRREELQKSIGHKPEPTDEEWELIKTVTEAHVATNAQGSHWKQKRKFLPEDIGQAPIVNAPEGGKVDLEAFSHFTKIITPAITRVVDFAKKLPMFCELPCEDQIILLKGCCMEIMSLRAAVRYDPESETLTLNGEMAVTRGQLKNGGLGVVSDAIFDLGMSLSSFNLDDTEVALLQAVLLMSSDRPGLACVERIEKYQDSFLLAFEHYINYRKHHVTHFWPKLLMKVTDLRMIGACHASRFLHMKVECPTELFPPLFLEVFED

Active Site
Feature Key Position(s) Description
Binding site 282 Thyroid hormone
Binding site 320 Thyroid hormone
Binding site 331 Thyroid hormone; via amide nitrogen
Binding site 435 Thyroid hormone
Structure

PDB:  3GWS

Show Surface
Site View
Reference
UniProt



Covalent Inhibitors

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Structure Rank ID Warhead Reaction Mechanism Target Site Activity Type Relation Value Unit Experiment Method Assay Reference