Thyroid hormone receptor alpha
Target information
- CovInDB Protein
- P10827
- Name
- Thyroid hormone receptor alpha
- Encoding Gene
- THRA
- Synonyms
-
- Thyroid hormone receptor alpha
- Nuclear receptor subfamily 1 group A member 1
- V-erbA-related protein 7
- EAR-7
- c-erbA-1
- c-erbA-alpha
- Taxonomy
- Homo sapiens (Human)
- Description
-
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.
- Sequence
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MEQKPSKVECGSDPEENSARSPDGKRKRKNGQCSLKTSMSGYIPSYLDKDEQCVVCGDKATGYHYRCITCEGCKGFFRRTIQKNLHPTYSCKYDSCCVIDKITRNQCQLCRFKKCIAVGMAMDLVLDDSKRVAKRKLIEQNRERRRKEEMIRSLQQRPEPTPEEWDLIHIATEAHRSTNAQGSHWKQRRKFLPDDIGQSPIVSMPDGDKVDLEAFSEFTKIITPAITRVVDFAKKLPMFSELPCEDQIILLKGCCMEIMSLRAAVRYDPESDTLTLSGEMAVKREQLKNGGLGVVSDAIFELGKSLSAFNLDDTEVALLQAVLLMSTDRSGLLCVDKIEKSQEAYLLAFEHYVNHRKHNIPHFWPKLLMKEREVQSSILYKGAAAEGRPGGSLGVHPEGQQLLGMHVVQGPQVRQLEQQLGEAGSLQGPVLQHQSPKSPQQRLLELLHRSGILHARAVCGEDDSSEADSPSSSEEEPEVCEDLAGNAASP
- Active Site
-
Feature Key Position(s) Description Binding site 228 Thyroid hormone Binding site 277 Thyroid hormone; via amide nitrogen - Structure
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PDB: 3ILZ
Show Surface - Reference
- UniProt
Covalent Inhibitors
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