Microtubule-associated protein tau
Target information
- CovInDB Protein
- P10636
- Name
- Microtubule-associated protein tau
- Encoding Gene
- MAPT
- Synonyms
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- Neurofibrillary tangle protein
- Paired helical filament-tau (PHF-tau)
- Taxonomy
- Homo sapiens (Human)
- Description
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Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311).
The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270).
Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization - Sequence
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MAEPRQEFEVMEDHAGTYGLGDRKDQGGYTMHQDQEGDTDAGLKESPLQTPTEDGSEEPGSETSDAKSTPTAEDVTAPLVDEGAPGKQAAAQPHTEIPEGTTAEEAGIGDTPSLEDEAAGHVTQEPESGKVVQEGFLREPGPPGLSHQLMSGMPGAPLLPEGPREATRQPSGTGPEDTEGGRHAPELLKHQLLGDLHQEGPPLKGAGGKERPGSKEEVDEDRDVDESSPQDSPPSKASPAQDGRPPQTAAREATSIPGFPAEGAIPLPVDFLSKVSTEIPASEPDGPSVGRAKGQDAPLEFTFHVEITPNVQKEQAHSEEHLGRAAFPGAPGEGPEARGPSLGEDTKEADLPEPSEKQPAAAPRGKPVSRVPQLKARMVSKSKDGTGSDDKKAKTSTRSSAKTLKNRPCLSPKHPTPGSSDPLIQPSSPAVCPEPPSSPKYVSSVTSRTGSSGAKEMKLKGADGKTKIATPRGAAPPGQKGQANATRIPAKTPPAPKTPPSSGEPPKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPPKSPSSAKSRLQTAPVPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGSKDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSKIGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSSTGSIDMVDSPQLATLADEVSASLAKQGL
- Active Site
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Feature Key Position(s) Description Site 24 Not glycated Site 381 Not glycated Site 391 Not glycated Site 392 Not glycated Site 394 Not glycated Site 44 Not glycated Site 465 Not glycated Site 497 Not glycated Site 507 Not glycated Site 541 Not glycated Site 557 Not glycated Site 571 Not glycated Site 574 Not glycated Site 584 Not glycated Site 591 Not glycated Site 607 Not glycated Site 611 Not glycated Site 615 Not glycated Site 628 Not glycated Site 634 Not glycated Site 638 Not glycated Site 648 Not glycated Site 657 Not glycated Site 660 Not glycated Site 67 Not glycated Site 687 Not glycated Site 692 Not glycated Site 700 Not glycated Site 702 Not glycated Site 712 Not glycated Site 755 Not glycated - Structure
- Not Available
- Reference
- UniProt
Covalent Inhibitors
| Structure | Rank | ID | Warhead | Reaction Mechanism | Target Site | Activity Type | Relation | Value | Unit | Experiment Method | Assay | Reference |
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