Steryl-sulfatase
Target information
- CovInDB Protein
- P08842
- Name
- Steryl-sulfatase
- Encoding Gene
- STS
- Synonyms
-
- Steryl-sulfatase
- Arylsulfatase C
- ASC
- Estrone sulfatase
- Steroid sulfatase
- Steryl-sulfate sulfohydrolase
- Taxonomy
- Homo sapiens (Human)
- Description
-
Catalyzes the conversion of sulfated steroid precursors, such as dehydroepiandrosterone sulfate (DHEA-S) and estrone sulfate to the free steroid.
- Sequence
-
MPLRKMKIPFLLLFFLWEAESHAASRPNIILVMADDLGIGDPGCYGNKTIRTPNIDRLASGGVKLTQHLAASPLCTPSRAAFMTGRYPVRSGMASWSRTGVFLFTASSGGLPTDEITFAKLLKDQGYSTALIGKWHLGMSCHSKTDFCHHPLHHGFNYFYGISLTNLRDCKPGEGSVFTTGFKRLVFLPLQIVGVTLLTLAALNCLGLLHVPLGVFFSLLFLAALILTLFLGFLHYFRPLNCFMMRNYEIIQQPMSYDNLTQRLTVEAAQFIQRNTETPFLLVLSYLHVHTALFSSKDFAGKSQHGVYGDAVEEMDWSVGQILNLLDELRLANDTLIYFTSDQGAHVEEVSSKGEIHGGSNGIYKGGKANNWEGGIRVPGILRWPRVIQAGQKIDEPTSNMDIFPTVAKLAGAPLPEDRIIDGRDLMPLLEGKSQRSDHEFLFHYCNAYLNAVRWHPQNSTSIWKAFFFTPNFNPVGSNGCFATHVCFCFGSYVTHHDPPLLFDISKDPRERNPLTPASEPRFYEILKVMQEAADRHTQTLPEVPDQFSWNNFLWKPWLQLCCPSTGLSCQCDREKQDKRLSR
- Active Site
-
Feature Key Position(s) Description Active site 136 None Metal binding 342 Calcium Metal binding 343 Calcium Metal binding 35 Calcium Metal binding 36 Calcium Active site 75 Nucleophile Metal binding 75 Calcium; via 3-oxoalanine - Structure
-
PDB: 1P49
Show Surface - Reference
- UniProt
Covalent Inhibitors
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