UDP-N-acetylenolpyruvoylglucosamine reductase

Target information

CovInDB Protein
P08373
Name
UDP-N-acetylenolpyruvoylglucosamine reductase
Encoding Gene
murB
Synonyms
  • UDP-N-acetylmuramate dehydrogenase
Taxonomy
Escherichia coli (strain K12)
Description

Cell wall formation.

Sequence

MNHSLKPWNTFGIDHNAQHIVCAEDEQQLLNAWQYATAEGQPVLILGEGSNVLFLEDYRGTVIINRIKGIEIHDEPDAWYLHVGAGENWHRLVKYTLQEGMPGLENLALIPGCVGSSPIQNIGAYGVELQRVCAYVDSVELATGKQVRLTAKECRFGYRDSIFKHEYQDRFAIVAVGLRLPKEWQPVLTYGDLTRLDPTTVTPQQVFNAVCHMRTTKLPDPKVNGNAGSFFKNPVVSAETAKALLSQFPTAPNYPQADGSVKLAAGWLIDQCQLKGMQIGGAAVHRQQALVLINEDNAKSEDVVQLAHHVRQKVGEKFNVWLEPEVRFIGASGEVSAVETIS

Active Site
Feature Key Position(s) Description
Active site 159 None
Binding site 190 Substrate
Active site 229 Proton donor
Active site 325 None
Structure

PDB:  2MBR

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Reference
UniProt



Covalent Inhibitors

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Structure Rank ID Warhead Reaction Mechanism Target Site Activity Type Relation Value Unit Experiment Method Assay Reference