Cathepsin B
Target information
- CovInDB Protein
- P07858
- Name
- Cathepsin B
- Encoding Gene
- CTSB
- Synonyms
-
- APP secretase
- APPS
- Cathepsin B1
- Taxonomy
- Homo sapiens (Human)
- Description
-
Thiol protease which is believed to participate in intracellular degradation and turnover of proteins (PubMed:12220505). Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis (PubMed:Sequence
MWQLWASLCCLLVLANARSRPSFHPLSDELVNYVNKRNTTWQAGHNFYNVDMSYLKRLCGTFLGGPKPPQRVMFTEDLKLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAHVSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVGCRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYNSYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGHAIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAGIPRTDQYWEKI
- Active Site
Feature Key Position(s) Description Active site 108 None Active site 278 None Active site 298 None - Structure
Check covalent ligand-protein complexes.
PDB: 6AY2
Show SurfaceSite View- Reference
- UniProt
Covalent Inhibitors
| Structure | Rank | ID | Warhead | Reaction Mechanism | Target Site | Activity Type | Relation | Value | Unit | Experiment Method | Assay | Reference |
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