Protein-glutamine gamma-glutamyltransferase 6
Target information
- CovInDB Protein
- O95932
- Name
- Protein-glutamine gamma-glutamyltransferase 6
- Encoding Gene
- TGM6
- Synonyms
-
- Transglutaminase Y
- TGY
- TGase Y
- Transglutaminase-3-like
- TGase-3-like
- Transglutaminase-6
- TG6
- TGase-6
- Taxonomy
- Homo sapiens (Human)
- Description
-
Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
- Sequence
-
MAGIRVTKVDWQRSRNGAAHHTQEYPCPELVVRRGQSFSLTLELSRALDCEEILIFTMETGPRASEALHTKAVFQTSELERGEGWTAAREAQMEKTLTVSLASPPSAVIGRYLLSIRLSSHRKHSNRRLGEFVLLFNPWCAEDDVFLASEEERQEYVLSDSGIIFRGVEKHIRAQGWNYGQFEEDILNICLSILDRSPGHQNNPATDVSCRHNPIYVTRVISAMVNSNNDRGVVQGQWQGKYGGGTSPLHWRGSVAILQKWLKGRYKPVKYGQCWVFAGVLCTVLRCLGIATRVVSNFNSAHDTDQNLSVDKYVDSFGRTLEDLTEDSMWNFHVWNESWFARQDLGPSYNGWQVLDATPQEESEGVFRCGPASVTAIREGDVHLAHDGPFVFAEVNADYITWLWHEDESRERVYSNTKKIGRCISTKAVGSDSRVDITDLYKYPEGSRKERQVYSKAVNRLFGVEASGRRIWIRRAGGRCLWRDDLLEPATKPSIAGKFKVLEPPMLGHDLRLALCLANLTSRAQRVRVNLSGATILYTRKPVAEILHESHAVRLGPQEEKRIPITISYSKYKEDLTEDKKILLAAMCLVTKGEKLLVEKDITLEDFITIKVLGPAMVGVAVTVEVTVVNPLIERVKDCALMVEGSGLLQEQLSIDVPTLEPQERASVQFDITPSKSGPRQLQVDLVSPHFPDIKGFVIVHVATAK
- Active Site
-
Feature Key Position(s) Description Metal binding 223 Calcium 1; via carbonyl oxygen Metal binding 226 Calcium 1 Metal binding 228 Calcium 1; via carbonyl oxygen Active site 274 None Metal binding 303 Calcium 2 Metal binding 305 Calcium 2 Metal binding 307 Calcium 2 Metal binding 309 Calcium 2; via carbonyl oxygen Metal binding 327 Calcium 2 Active site 333 None Active site 356 None Metal binding 396 Calcium 3 Metal binding 417 Calcium 3; via carbonyl oxygen Metal binding 445 Calcium 3 Metal binding 450 Calcium 3 - Structure
- Not Available
- Reference
- UniProt
Covalent Inhibitors
| Structure | Rank | ID | Warhead | Reaction Mechanism | Target Site | Activity Type | Relation | Value | Unit | Experiment Method | Assay | Reference |
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