1-[(3R,4R)-3-[[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-hydroxypyrrolidin-1-yl]prop-2-en-1-one

Inhibitor information

CovInDB Inhibitor
CI001525
Name
1-[(3R,4R)-3-[[5-Chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-hydroxypyrrolidin-1-yl]prop-2-en-1-one
Molecular Formula
C18H20ClN7O3
Molecular Weight
417.8 g/mol
Structure
2D structure
  Warhead   Similar Compounds
IUPAC Name
1-[(3R,4R)-3-[[5-chloro-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxymethyl]-4-hydroxy-pyrrolidin-1-yl]prop-2-en-1-one
InChI
InChI=1S/C18H20ClN7O3/c1-3-14(28)26-6-10(13(27)8-26)9-29-17-15-12(19)5-20-16(15)23-18(24-17)22-11-4-21-25(2)7-11/h3-5,7,10,13,27H,1,6,8-9H2,2H3,(H2,20,22,23,24)/t10-,13+/m1/s1
InChI Key
WXAGFSCXMRRCME-MFKMUULPSA-N
Canonical SMILES
C=CC(=O)N1C[C@H](O)[C@@H](COc2nc(Nc3cnn(C)c3)nc3[nH]cc(Cl)c23)C1
Cocrystal structures
No cocrystal structures found for this inhibitor.


Calculated Properties

Molecular Weight

417.8 g/mol

Computed by RDKit

logP

1.9

Computed by ALOGPS

logS

-2.96

Computed by ALOGPS

Heavy Atom Count

29

Computed by RDKit

Ring Count

4

Computed by RDKit

Hydrogen Bond Acceptor Count

8

Computed by RDKit

Hydrogen Bond Donor Count

3

Computed by RDKit

Rotatable Bond Count

6

Computed by RDKit

Topological Polar Surface Area

121.19 Å2

Computed by RDKit



3D Structure

  Show Warhead


targets

Name ID Warhead Reaction Mechanism Target Site Activity Type Relation Value Unit Experiment Method Assay Reference


Similar compounds in Virtual Screening library

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ZC1273542

Similarity Score: 0.84

ZC1274601

Similarity Score: 0.84



Similar Natural compounds

No similar natural compounds found for this inhibitor.